Title

Synthesis of the Isomeric Analogue of PQQ known as Ethyl pyruvate 2-methoxy-5-nitrophenylhydrazone.

Authors

Christine Le

Document Type

Article

Publication Date

2000

Abstract

In endeavoring to better understand the substance known as PQQ, the synthesis of the isomeric analogue ethyl pyruvate 2-methoxy-5- nitrophenylhydrazone was attempted. The synthesis consists of seven steps, where the first two involved first the formation of a diazonium salt subsequently reacting with a solution of ethyl-2-methylacetoacetate in slightly basic buffer. Difficulties were found in obtaining the product in purity?the major side product which resulted from ethoxy cleavage rather than acetyl was determined to be dependent upon the pH of the buffer solution and possibly the temperature of the reaction.

Advisor

Tetsuo Otsuki

Department

chem

Support

National Science Foundation-Research Experience for Undergraduates Grant

This document is currently not available here.

Share

COinS