The Enantioselective Synthesis of Isofagomine: A Glycosidase Inhibitor That Packs More Punch Than Chuck Norris
A novel stereoselective synthesis of isofagomine using a readily available enzyme is described. Crotonaldehyde is transformed in eight steps harnessing the power of Mother Nature along with a series of organometallic catalyzed processes such as ruthenium-catalyzed cross-metathesis, allyl palladium substitutions, and palladium reductions giving way to a spontaneous intramolecular ring closing.
Heffner, Michael, " The Enantioselective Synthesis of Isofagomine: A Glycosidase Inhibitor That Packs More Punch Than Chuck Norris" (2006). URC Student Scholarship.
Sherman Fairchild Foundation Grant