Title

The Enantioselective Synthesis of Isofagomine: A Glycosidase Inhibitor That Packs More Punch Than Chuck Norris

Authors

Michael Heffner

Document Type

Article

Publication Date

2006

Abstract

A novel stereoselective synthesis of isofagomine using a readily available enzyme is described. Crotonaldehyde is transformed in eight steps harnessing the power of Mother Nature along with a series of organometallic catalyzed processes such as ruthenium-catalyzed cross-metathesis, allyl palladium substitutions, and palladium reductions giving way to a spontaneous intramolecular ring closing.

Advisor

Donald Deardorff

Department

chem

Support

Sherman Fairchild Foundation Grant

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