Title

An Enantioselective Synthesis of Cymbalta: Preparation of (+)-(S)-Duloxetine

Authors

Nikhil Addleman

Document Type

Article

Publication Date

2008

Abstract

Duloxitine is a serotonin-norepinephrine reuptake inhibitor used in the treatment of depression and anxiety. Duloxetine's chiral structure makes it an excellent target for using our novel enantioselective synthesis techniques. The proposed synthetic route establishes asymmetry by use of an enzyme and maintains chirality while adding functionality to the molecular backbone through palladium p-allyl substitution and ruthenium catalyzed cross metathesis.

Advisor

Donald Deardorff

Department

chem

Support

Howard Hughes Medical Institute Undergraduate Science Education Grant

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