Title
An Enantioselective Synthesis of Cymbalta: Preparation of (+)-(S)-Duloxetine
Document Type
Article
Publication Date
2008
Abstract
Duloxitine is a serotonin-norepinephrine reuptake inhibitor used in the treatment of depression and anxiety. Duloxetine's chiral structure makes it an excellent target for using our novel enantioselective synthesis techniques. The proposed synthetic route establishes asymmetry by use of an enzyme and maintains chirality while adding functionality to the molecular backbone through palladium p-allyl substitution and ruthenium catalyzed cross metathesis.
Recommended Citation
Addleman, Nikhil, " An Enantioselective Synthesis of Cymbalta: Preparation of (+)-(S)-Duloxetine" (2008). URC Student Scholarship.
http://scholar.oxy.edu/urc_student/314
Advisor
Donald Deardorff
Department
chem
Support
Howard Hughes Medical Institute Undergraduate Science Education Grant
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