Title

Enantiopure Synthesis of (-)-Coniine

Authors

David Weiser

Document Type

Article

Publication Date

2008

Abstract

Coniine is a toxic alkaloid that is isolated from spotted hemlock.The molecule has been a popular synthetic target for showcasing new methods of enantioselective synthesis. Our own strategy for the synthesis of coniine blends the enantioselectivity of an enzyme with the rich organometallic chemistry of p-allyl palladium substitutions and ruthenium-catalyzed ring-closing metathesis.

Advisor

Donald Deardorff

Department

chem

Support

Howard Hughes Medical Institute Undergraduate Science Education Grant

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