Title

Enantioselective Synthesis of a Natural Product: Coniine Jeffrey Cannon and Jason Papazian

Document Type

Article

Publication Date

2005

Abstract

Stereochemistry and enantiopurity are important aspects of biologically active molecules. Our research uses synthetic methods that create and expand upon enantiopurity. Using an enzyme to produce a chiral starting material, we are able to manipulate the molecule towards a synthetic goal while preserving the stereochemistry. The enzymatically derived starting material is elaborated upon using a novel synthesis involving palladium(0) and Grubbs catalysts. Using these methods we are able to synthesize a natural product that showcases the power of our methodology and the stereoselectivity of our procedures.

Advisor

Donald R. Deardorff

Department

chem

Support

Norris Scholars Program and C. David West Fellowship

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