Enantioselective Synthesis of a Natural Product: Coniine Jeffrey Cannon and Jason Papazian
Stereochemistry and enantiopurity are important aspects of biologically active molecules. Our research uses synthetic methods that create and expand upon enantiopurity. Using an enzyme to produce a chiral starting material, we are able to manipulate the molecule towards a synthetic goal while preserving the stereochemistry. The enzymatically derived starting material is elaborated upon using a novel synthesis involving palladium(0) and Grubbs catalysts. Using these methods we are able to synthesize a natural product that showcases the power of our methodology and the stereoselectivity of our procedures.
Cannon, Jeffrey and Papazian, Jason, " Enantioselective Synthesis of a Natural Product: Coniine Jeffrey Cannon and Jason Papazian " (2005). URC Student Scholarship.
Donald R. Deardorff
Norris Scholars Program and C. David West Fellowship