Title

The Effects of Cholesterol on Lipid Bilayers

Authors

Samuel Shin

Document Type

Article

Publication Date

2002

Abstract

Differential scanning calorimetry (DSC) was used to study the effects of cholesterol on the thermotropic phase behavior of fully hydrated 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). DPPC was studied with cholesterol ranging from 0 to 22 mol% cholesterol over a temperature range from 20 to 50?C. DSC studies show a decrease in the main transition temperature (Tm) for DPPC with concentrations of cholesterol increasing up to 12 mol%. However, at concentrations greater than 12 mol%, there is an increase in Tm for DPPC. The pre-transition for DPPC was also found to be diminished at cholesterol concentrations greater than 5 mol%.

Advisor

P. Dea

Department

chem

Support

Support provided by:National Science Foundation-Research Experience for Undergraduates Fellowship

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