Title

Effects of Pentanol Isomers on the Phase Behavior of Phospholipid Bilayer Membranes

Authors

Kathryn Griffin

Document Type

Article

Publication Date

2008

Abstract

Differential scanning calorimetry (DSC) was used to analyze the thermotropic phase behavior of dipalmitoylphosphatidylcholine (DPPC) bilayers in the presence of pentanol isomers. Heating and cooling scans were run as a function of concentration of each isomer. Sufficient data was collected to determine the concentration of each pentanol needed to induce the interdigitated phase by the appearance of a biphasic effect in the main transition temperatures, the onset of a hysteresis associated with the main transition from gel-to-liquid crystalline phase, and the disappearance of the pretransition. Lower threshold concentrations were found to correlate with isomers of greater alkyl chain length while branching of the alkyl chain was found to increase biphasic behavior. However, as demonstrated in the DPPC/neopentyl alcohol system, branching of the alkyl chain away from the ?OH group lowers the threshold concentration while maintaining a biphasic effect.

Advisor

Phoebe Dea

Department

chem

Support

Fletcher-Jones Chemistry Research Fund

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