Browsing Chemistry URC Student Scholarship by Title
Now showing items 1-20 of 276
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31P NMR Studies: Lipid Phase Transitions and Drug Interactions.
(2000-01-01)Hydrated dipalmitoylphosphatidylcholine (DPPC) multilayers were used as a model membrane system to study the interactions of chlorpromazine hydrochloride (CPZ.HCl) on the lipid phase transition via <sup>31</sup>P NMR ... -
A 31P NMR and Calorimetry Study: The Effects of an Antipsychotic Drug on Lipid Bilayers
(2001-01-01)Hydrated dipalmitoylphosphatidylcholine (DPPC) multilayers were used as a model membrane system to study the effects of the antipsychotic drug chlorpromazine hydrochloride (CPZ) on the lipid phase transitions via <sup>31</sup>P ... -
A Morphological Investigation of the Co-existence of Host-Dependent Bdellovibrio bacteriovorus and its Host-Independent Variants by Atomic Force Microscopy
(2011-01-01)The persistence in the environment of Bdellovibrio bacteriovorus , a Gram-negative bacterium that hunts and invades other Gram-negative bacteria in its host-dependent lifestyle, is the underlying scientific theme of this ... -
A New Heterogeneous Method of CLICK Reactions for Biological Conjugations
(2010-01-01)The simple and fast CLICK reaction, in which an azide is linked to an alkyne, has been used extensively to produce substances promptly and reliably. These reactions commonly require ascorbic acid and organic solvents, ... -
A Route to Amphiphilic Silver Nanoparticles Juan D. Guerrero and Oanh Phan
(2002-01-01)A quantum dot or nanoparticle is a unique state of matter. Quantum dots are composed of thousands of metal atoms. These tiny crystals range in size from 1 to 100 nanometers and confine electrons on the nanometer scale. As ... -
A Simplified and Greener Approach to Patterning Surfaces with Metallic Nanostructures
(2011-01-01)Marangoni flow is a phenomenon that spontaneously drives mass motion when surface tension gradients are created from surfactant concentration, temperature, and electrostatic potential across immiscible fluids. It has been ... -
A Single Enantiomer Preparation of Prozac? and a Novel Synthesis of Amides
(2002-01-01)Several modern-day pharmaceuticals consist of molecules that are chiral. These molecules are of special importance because they are composed of enantiomers. Enantiomers are nearly identical molecules that are non-superimposable ... -
A Study of an Insight into the Reactivity of 1,4-Naphthoquinone Derivatives
(2010-01-01)Understanding the reactivity of 1,4-naphthoquinones is interesting in two different aspects; as a redox agent and as a conjugated-carbonyl electrophile. In biological systems, they function as a redox component that is ... -
A Study of Soluble Glucose Dehydrogenase Based upon Kinetic Studies of the Structural Analogs of PQQ. James Ewing, Leslie Thompson & Carolnn Yong
(1999-01-01)Soluble glucose dehydrogenase is a homodimeric enzyme found in various bacteria such as Acinetobacter calcoaceticus , requiring Ca<sup>2+</sup> and pyrroloquinolinequinone (PQQ) cofactors for full enzymatic activity. sGDH ... -
A Supramolecular Assembly for Solar-Energy Storage
(1999-01-01)Our research is directed toward the solar-energy conversion of water to molecular hydrogen. A cheap method of producing H2 would not only provide an abundant energy source, but would also alleviate many of the environmental ... -
A Two-step Method for the Conversion of a.b-Unsaturated Aldehydes into g-Azido-a,b-Unsaturated Nitriles. Sanaz Tafti, Henry Kim & Cullen Tanaguchi
(1999-01-01)g-Azido-a,b-unsaturated nitriles are important synthetic intermediates due to their versatility as precursors to many diverse organic compounds. We have developed a fast, convenient and efficient two-step method for ... -
Activation of Bleomycin at DNA Modified Electrodes Chris Jackson & Hayden Burgoyne
(2007-01-01)Whether or not DNA acts as an effective electron transporter has been a controversial issue since the 1960s, when Ely and Spivey first predicted the possible electroconductivity of the genetic carrier<sup>1</sup>. Recent ... -
Activation of Cytochrome P450 Enzyme at a Surfactant Film Electrode. Nareen Hindoyan and Bridgett Sabat
(2004-01-01)We are investigating the redox chemistry of the heme domains of wild type BM3 (WT) and mutant 1-12G. Compared to WT, 1-12G combines 16 amino acid mutations to produce BM3 variants that show high activity towards a variety ... -
An Asymmetric Synthesis of Prozac
(2010-01-01)A total enantioselective synthesis of the SSRI (-)-Fluoxetine (Prozac?) is presented. Selective Serotonin Reuptake Inhibitors (SSRIs) work to prevent the reabsorption of serotonin, thus increasing the extracellular ... -
An Electrochemical Model for Interfacial Protein Interactions.
(2004-01-01)The goal of this research is to study the role tryptophan 48 plays in the oxidation-reduction chemistry of azurin: a mononuclear blue copper protein found in the gram-negative bacterium Pseudomonas aeruginosa. Trp48, which ... -
An Enantioselective Synthesis of (-)-Coniine
(2009-01-01)Enantioselective syntheses have become increasingly important since the FDA declared enantiomers as separate chemical entities in the late nineties. (-)-coniine, a natural product derived from spotted Hemlock is responsible ... -
An Enantioselective Synthesis of a Single Enantiomer of Prozac; Preparation of (S)-(+)-Fluoxetine
(2008-01-01)An enantioselective synthesis of S-(+)-Fluoxetine is shown by utilizing the enzyme (R)-oxynitrilase to induce chirality, in high enantiomeric excess, in trans-cinnamaldehyde to form (R,E)-2-hydroxy-4-phenylbut-3-enenitrile. ... -
An Enantioselective Synthesis of Cymbalta: Preparation of (+)-(S)-Duloxetine
(2008-01-01)Duloxitine is a serotonin-norepinephrine reuptake inhibitor used in the treatment of depression and anxiety. Duloxetine's chiral structure makes it an excellent target for using our novel enantioselective synthesis techniques. ... -
An Enantioselective Synthesis of CymbaltaTM
(2010-01-01)Duloxetine or Cymbalta? is a potent antidepressant which targets neural serotonin channels, making it successful at treating patients with major depressive disorder, generalized anxiety disorder, diabetic neuropathy and ... -
An Enantioselective Synthesis of CymbaltaTM Colin McKinlay and Vincent van Rixel
(2010-01-01)A complete synthesis of Duloxetine, marketed as Cymbalta?, is achieved using an enantiomerically conserved route. Cymbalta? is a potent antidepressant which targets neural serotonin channels, making it successful at treating ...