An Enantioselective Synthesis of Cymbalta: Preparation of (+)-(S)-Duloxetine
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Duloxitine is a serotonin-norepinephrine reuptake inhibitor used in the treatment of depression and anxiety. Duloxetine's chiral structure makes it an excellent target for using our novel enantioselective synthesis techniques. The proposed synthetic route establishes asymmetry by use of an enzyme and maintains chirality while adding functionality to the molecular backbone through palladium p-allyl substitution and ruthenium catalyzed cross metathesis.