Show simple item record

dc.contributor.advisorDeardorff, Don
dc.contributor.authorAddleman, Nikhil
dc.date.accessioned2020-08-13T14:55:52Z
dc.date.available2020-08-13T14:55:52Z
dc.date.issued2008-01-01 0:00
dc.identifier.urihttps://scholar.oxy.edu/handle/20.500.12711/576
dc.description.abstractDuloxitine is a serotonin-norepinephrine reuptake inhibitor used in the treatment of depression and anxiety. Duloxetine's chiral structure makes it an excellent target for using our novel enantioselective synthesis techniques. The proposed synthetic route establishes asymmetry by use of an enzyme and maintains chirality while adding functionality to the molecular backbone through palladium p-allyl substitution and ruthenium catalyzed cross metathesis.
dc.description.sponsorshipHoward Hughes Medical Institute Undergraduate Science Education Grant
dc.titleAn Enantioselective Synthesis of Cymbalta: Preparation of (+)-(S)-Duloxetine
dc.typearticle
dc.abstract.formathtml
dc.description.departmentchem
dc.source.issueurc_student
dc.source.issueurc_student
dc.identifier.legacyhttps://scholar.oxy.edu/urc_student/314
dc.source.statuspublished


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record