Stereochemistry and enantiopurity are important aspects of biologically active molecules. Our research uses synthetic methods that create and expand upon enantiopurity. Using an enzyme to produce a chiral starting material, we are able to manipulate the molecule towards a synthetic goal while preserving the stereochemistry. The enzymatically derived starting material is elaborated upon using a novel synthesis involving palladium(0) and Grubbs catalysts. Using these methods we are able to synthesize a natural product that showcases the power of our methodology and the stereoselectivity of our procedures.