Enantioselective Synthesis of a Natural Product: Coniine Jeffrey Cannon and Jason Papazian
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Stereochemistry and enantiopurity are important aspects of biologically active molecules. Our research uses synthetic methods that create and expand upon enantiopurity. Using an enzyme to produce a chiral starting material, we are able to manipulate the molecule towards a synthetic goal while preserving the stereochemistry. The enzymatically derived starting material is elaborated upon using a novel synthesis involving palladium(0) and Grubbs catalysts. Using these methods we are able to synthesize a natural product that showcases the power of our methodology and the stereoselectivity of our procedures.