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dc.contributor.advisorDeardorff, Don
dc.contributor.authorFinlayson, Chris
dc.contributor.authorPace, Andrew
dc.date.accessioned2020-08-13T14:55:52Z
dc.date.available2020-08-13T14:55:52Z
dc.date.issued2005-01-01 0:00
dc.identifier.urihttps://scholar.oxy.edu/handle/20.500.12711/581
dc.description.abstractAnisomycin, a biologically important pyrrolidine, was formally synthesized using a strategy incorporating the enantioselectivity of oxynitrilase, the power of olefin cross metathesis, and the rich chemistry of palladium pi-allyls. Overall, this coupled methodology afforded a strategic anisomycin intermediate in excellent chemical and optical yields (&gt;95% ee). An olefin cross-metathesis reaction between an enzyme-derived chiral fragment and other functionalized alkenes extends the versatility of oxynitrilase in synthesis.<i style="mso-bidi-font-style:normal">
dc.titleElaboration of an Enzymatically-Derived Chiral Fragment via Olefin Cross Metathesis: A Novel Strategy for the Synthesis of Polyhydroxylated Pyrrolidines Chris Finlayson, Andrew Pace, and Kathryn Watts
dc.typearticle
dc.abstract.formathtml
dc.description.departmentchem
dc.source.issueurc_student
dc.source.issueurc_student
dc.identifier.legacyhttps://scholar.oxy.edu/urc_student/322
dc.source.statuspublished


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