| dc.contributor.advisor | Deardorff, Don | |
| dc.contributor.author | Finlayson, Chris | |
| dc.contributor.author | Pace, Andrew | |
| dc.date.accessioned | 2020-08-13T14:55:52Z | |
| dc.date.available | 2020-08-13T14:55:52Z | |
| dc.date.issued | 2005-01-01 0:00 | |
| dc.identifier.uri | https://scholar.oxy.edu/handle/20.500.12711/581 | |
| dc.description.abstract | Anisomycin, a biologically important pyrrolidine, was formally synthesized using a strategy incorporating the enantioselectivity of oxynitrilase, the power of olefin cross metathesis, and the rich chemistry of palladium pi-allyls. Overall, this coupled methodology afforded a strategic anisomycin intermediate in excellent chemical and optical yields (>95% ee). An olefin cross-metathesis reaction between an enzyme-derived chiral fragment and other functionalized alkenes extends the versatility of oxynitrilase in synthesis.<i style="mso-bidi-font-style:normal"> | |
| dc.title | Elaboration of an Enzymatically-Derived Chiral Fragment via Olefin Cross Metathesis: A Novel Strategy for the Synthesis of Polyhydroxylated Pyrrolidines Chris Finlayson, Andrew Pace, and Kathryn Watts | |
| dc.type | article | |
| dc.abstract.format | html | |
| dc.description.department | chem | |
| dc.source.issue | urc_student | |
| dc.source.issue | urc_student | |
| dc.identifier.legacy | https://scholar.oxy.edu/urc_student/322 | |
| dc.source.status | published | |
