• Login
    View Item 
    •   Oxy Scholar Home
    • Chemistry
    • Chemistry URC Student Scholarship
    • View Item
    •   Oxy Scholar Home
    • Chemistry
    • Chemistry URC Student Scholarship
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Effect of Unsaturation on Ethanol-Induced Interdigitation in Model Lipid Bilayers Bennett Addison and Eric Smith

    Thumbnail
    Author
    Addison, Bennett; Smith, Erc
    Issue
    urc_student; urc_student
    Date
    2006-01-01 0:00
    Metadata
    Show full item record
    URI
    https://scholar.oxy.edu/handle/20.500.12711/582
    Abstract
    Differential scanning calorimetry (DSC) was used to observe the effect of unsaturation on phase transition temperatures of model lipid bilayers. In the presence of ethanol, pure 1,2-Diarachidoyl-sn-Glycero-3-Phosphocholine (DAPC), a synthetic lipid with two saturated 20 carbon-length acyl chains is known to interdigitate when the bilayer transitions between planar gel phase Lb? and liquid crystalline phase La. This interdigitation is signified by a biphasic effect while plotting phase transition temperature versus ethanol concentration. DAPC samples were hydrated with various concentrations of ethanol, and the biphasic plot was observed. Unsaturated lipids were then introduced to observe their effects on the phase transition temperatures and interdigitation. 1,2-Dieicosenoyl-sn-Glycero-3-Phosphocholine (DEiPC), a synthetic lipid with both acyl chains of 20 carbons and a cis double bond on both 11th carbons, was mixed with DAPC. Different mixtures of saturated and unsaturated lipids were prepared. The effect of ethanol was observed for each mixture using DSC. By increasing the percentage of unsaturation and therefore decreasing bilayer stability, the phase transition temperature was expected to decrease and the threshold concentration (concentration needed to induce interdigitation) to increase. Both effects were observed, but only to a small degree. Multiple hypotheses are currently being tested to explain this observation.
    Collections
    • Chemistry URC Student Scholarship

    Browse

    All of Oxy ScholarCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsJournal TitleJournal IssueThis CollectionBy Issue DateAuthorsTitlesSubjectsJournal TitleJournal Issue

    My Account

    LoginRegister

    DSpace software copyright © 2002-2021  DuraSpace
    Contact Us | Send Feedback
    DSpace Express is a service operated by 
    Atmire NV