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dc.contributor.advisorDea, Pheobe
dc.contributor.authorTehrani, Shandiz
dc.date.accessioned2020-08-13T14:55:58Z
dc.date.available2020-08-13T14:55:58Z
dc.date.issued1999-01-01 0:00
dc.identifier.urihttps://scholar.oxy.edu/handle/20.500.12711/674
dc.description.abstractThe mean aggregate number (MAN) of the antipsychotic drug chlorpromazine hydro-chloride (CPZ) was investigated by fluorescence quenching. Using the intrinsic fluorescent properties of CPZ micelles and the quenching effect of 9-methylanthracene (9-MA), the MAN was determined to be ca. 30. A pronounced increase in aggregate size with in-creasing drug concentration (0.005-0.020 M CPZ) further confirmed the stepwise aggregation theory of CPZ. Increasing temperatures (>313 K) hindered the stability of larger micelles. Increasing electrolyte concentrations (0.0-0.4 M NaCl) resulted in increasing aggregate size, while higher osmotic pressures (0.0-0.3 M dextrose) had no significant effect on the micelle size. The enthalpy of micellization and demicellization for CPZ in a buffered solution were measured by differential scanning calorimetry. Post-micelle solutions of CPZ in buffer showed an abrupt, endothermic peak during upscans at ca. 318 E K. The peak was assigned as that of demicellization. Down scans revealed a broad peak due to the heat of micellization. Integration of peaks revealed changes in enthalpy values of -9 and 9 kJ per mole for micellization and demicellization respectively.
dc.description.sponsorshipSupport provided by:Beckman Scholars Program
dc.titleChlorpromazine Hydrochloride Micellization and the Thermodynamics of Aggregation in Aqueous Solution.
dc.typearticle
dc.abstract.formathtml
dc.description.departmentchem
dc.source.issueurc_student
dc.source.issueurc_student
dc.identifier.legacyhttps://scholar.oxy.edu/urc_student/924
dc.source.statuspublished


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