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dc.contributor.advisorOtsuki, Testuo
dc.contributor.authorWilliams, Rachael Y 0:00
dc.description.abstractStreptonigrin, a derivative of 7-amino-6-methoxy-5,8-quinolinequinone, was first isolated from the bacterium Streptomyces flocculus forty years ago. It has proven to be a good substrate of NAD(P)H: quinone oxidoreductase, which is over expressed in tumors of the colon, breasts and lungs. It is suggested that the enzymatic process of NAD(P)H: quinone oxidoreductase with streptonigrin produces hydroxy (OH) radical that induces the breakage of DNA strands and consequently, various cell toxins. Recently, a less complicated family of streptonigrin has proven to be a more effective substrate for the NAD(P)H: quinone oxidoreductase. The most simple member of this family, 6-methoxy-5,8-quinolinequinone, is prepared via a four-step synthesis starting from the commercially available 6-hydroxyquinoline. Thus far, we have synthesized 6-methoxy-5, 8-quinolinequinone. We now plan to introduce various N substituents at the compound's 7th position producing a structure that better resembles that of streptonigrin's. We expect this new family to be a better substrate for NAD(P)H: quinone oxidoreductase, thus functioning as a more effective antitumor agent.
dc.description.sponsorshipNational Science Foundation-Research Experience for Undergraduates Fellowship
dc.titleSynthesis of7-Amino-6-methoxy-5,8-quinolinequinone Derivatives

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