• Login
    View Item 
    •   Oxy Scholar Home
    • Chemistry
    • Chemistry URC Student Scholarship
    • View Item
    •   Oxy Scholar Home
    • Chemistry
    • Chemistry URC Student Scholarship
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    An Enantioselective Synthesis of Prozac

    Thumbnail
    Author
    Griffin, Jennifer
    Issue
    urc_student; urc_student
    Date
    2011-01-01 0:00
    Metadata
    Show full item record
    URI
    https://scholar.oxy.edu/handle/20.500.12711/783
    Abstract
    The enantioselective synthesis of (S)-Fluoxetine, also known as Prozac<sup>?</sup>, is presented. As a selective serotonin reuptake inhibitor, Prozac<sup>?</sup> prevents the reabsorption of the neurotransmitter serotonin into the pre-synaptic cell, thereby increasing its extracellular concentration. Low extracellular concentrations of serotonin are known to cause depression, anxiety, and personality disorders. While Prozac<sup>?</sup> is marketed as a racemic drug, one of its enantiomers, (S)-fluoxetine, has been proven to exhibit greater physiological activity. Our unique synthetic approach begins with the induction of asymmetry in the achiral starting material with the inexpensive yet powerful enzyme oxynitrilase, which we isolate from commercial grade raw almonds. The crucial palladium-catalyzed chiral shift reaction transfers the stereocenter and introduces necessary functionality, while preserving high levels of enantiopurity.
    Collections
    • Chemistry URC Student Scholarship

    Browse

    All of Oxy ScholarCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsJournal TitleJournal IssueThis CollectionBy Issue DateAuthorsTitlesSubjectsJournal TitleJournal Issue

    My Account

    LoginRegister

    DSpace software copyright © 2002-2021  DuraSpace
    Contact Us | Send Feedback
    DSpace Express is a service operated by 
    Atmire NV