Enantiopure Synthesis of (-)-Coniine
Coniine is a toxic alkaloid that is isolated from spotted hemlock.The molecule has been a popular synthetic target for showcasing new methods of enantioselective synthesis. Our own strategy for the synthesis of coniine blends the enantioselectivity of an enzyme with the rich organometallic chemistry of p-allyl palladium substitutions and ruthenium-catalyzed ring-closing metathesis.
Weiser, David, " Enantiopure Synthesis of (-)-Coniine" (2008). URC Student Scholarship.
Howard Hughes Medical Institute Undergraduate Science Education Grant