Heparin Mimics for Chemotherapy Using Polyvalent Displays on Virus Particles
Constrained global supplies and pleas for pure preparations have fueled demand for easily derived and well-defined heparin synthetics. This is particularly urgent given heparin?s increasingly recognized role in carcinogenesis, necessitating well-defined molecules for unambiguous structure-function studies. Our research proposes to use virus particles as controlled, addressable polyvalent scaffolds for the display of sulfated sugars that act as heparin mimics. Currently I have synthesized two sulfated molecules that will attach at precise positions on modified virus particles via highly selective and quantitative ?Click? chemistry. These novel particles will then be assessed for their ability to elicit biological activity in vitro using a range of assays (carcinogenic activity, bleeding, etc.)
Drugan, Daniel, "Heparin Mimics for Chemotherapy Using Polyvalent Displays on Virus Particles" (2009). URC Student Scholarship.
Howard Hughes Medical Institute Undergraduate Science Education Grant